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Mechanism of Action

Artesunate is a hemisuccinate derivative of dihydroartemisinin, which is itself formed by the reduction of artemisinin. The mechanism of action of artemisinins probably involves the cleavage of the internal endoperoxide bridge by reaction with a haem inside the infected erythrocyte, thus generating free radicals which alkylate the vital proteins of the parasite. However, it has also been reported that artemisinins inhibit an essential parasite, adenosine triphosphatase calcium.

Injections

Effective in malaria in Plasmodium Vivax and Plasmodium falciparum
THE EXPERT NO RESISTANCE IN MALARIA ...

  • Plasmodium Falciparum malaria
  • Severe malaria
  • Multidrug-resistant malaria
  • Cerebral malaria
Dosage

Injections:

Artesunate Injection 120 mg

  • 2.4 mg / kg repeated at 12 h and 24 h by IM / IV OR as prescribed by the doctor


pharsunate
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