Diclofenac sodium is a non-steroidal agent with marked analgesic / anti-inflammatory properties. It is an inhibitor of prostaglandin synthetase, (cyclo-oxygenase). Diclofenac sodium in vitro does not suppress proteoglycan biosynthesis in cartilage at concentrations equivalent to the concentrations reached in human beings.
It is an aniline derivative with analgesic and antipyretic actions similar to those of aspirin, but with no demonstrable anti-inflammatory activity. Paracetamol is less irritant to the stomach than aspirin. It does not affect thrombocyte aggregation or bleeding time. Paracetamol is generally well tolerated by patients hypersensitive to acetylsalicylic acid.
Analgesic Action: The central analgesic action of paracetamol resembles that of aspirin. It produces analgesia by raising the pain threshold.
Antipyretic Effect: The antipyretic effect of paracetamol is attributed to its ability to inhibit COX in the brain where the peroxide tone is low. Recent evidence suggests inhibition of COX-3 (believed to be a splice variant product of the COX-1 gene) and could represent a primary central mechanism by which paracetamol decreases pain and, possibly, fever.
It binds to alpha-2-macroglobulin in the blood in the ratio of 1:1, which helps to mask its antigenicity, but retain its enzymatic activity. Levels of serratiopeptidase are slowly transferred to the exudate at the site of inflammation and gradually, the blood level declines. By hydrolyzing bradykinin, histamine and serotonin, it indirectly reduces dilatation of blood capillaries and controls permeability. Serratiopeptidase blocks plasmin inhibitors, thus helping the fibrinolytic activity of plasmin. Degradation of extra-fibrin to small fragment prevents the clogging of microcapillaries, helps clearance of exudates, reduces swelling and improves microcirculation.
Paradik is indicated for the treatment of
(Diclofenac Sodium 50 mg, Paracetamol 500 mg & Serratiopeptidase 15 mg Tablets)
(Diclofenac Sodium 50 mg & Paracetamol 500 mg Tablets)
The maximum recommended dose of PARADIK FORTE TABLETS / PARADIK TABLETS is two tablets a day, one tablet in the morning and one tablet in the evening. Or as prescribed by the doctor.
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