Mechanism of Action
- Albendazole binds to the colchicine-sensitive site of β-tubulin inhibiting their polymerization into microtubules.
- The decrease in microtubules in the intestinal cells of the parasites decreases their absorptive function, especially the uptake of glucose by the adult and larval forms of the parasites, and also depletes glycogen storage.
- Insufficient glucose results in insufficient energy for the production of adenosine trisphosphate (ATP) and the parasite eventually dies.